Haji-Ghassemi Research Lab


Structures of PKA-phospholamban complexes reveal a mechanism of familial dilated cardiomyopathy.

Qin, J; Zhang, J; Lin, L; Haji-Ghassemi, O; Lin, Z; Woycechowsky, KJ; Van Petegem, F; Zhang, Y; Yuchi, Z. Elife.

2021 2020
A rare cacna1h variant associated with amyotrophic lateral sclerosis causes complete loss of CaV3.2 T-type channel activity.

Stringer RN, Jurkovicova-Tarabova B, Huang S, Haji-Ghassemi O, Idoux R, Liashenko A, Souza IA, Rzhepetskyy Y, Lacinova L, Van Petegem F, Zamponi GW, Pamphlett R, Weiss N.  Mol. Brain.

Structural basis for diamide modulation of ryanodine receptor.

Ma R*, Haji-Ghassemi O*, Ma D*, Jiang H*, Lin L, Yao L, Samurkas A, Li Y, Wang Y, Cao P, Wu S, Zhang Y, Murayama T, Moussian B, Van Petegem F, Yuchi Z. Nat. Chem. Biol. [*co-first]

Subtle changes in the combining site of the chlamydiaceae-specific mAb S25-23 increase the antibody-carbohydrate binding affinity by an order of magnitude.

Haji-Ghassemi O, Muller-Loennies S, Brooks CL, MacKenzie CR, Caveney N, Van Petegem F, Brade L, Kosma P, Brade H, Evans SV. Biochemistry


The cardiac ryanodine receptor phosphorylation hotspot embraces PKA in a phosphorylation-dependent manner.

Haji-Ghassemi O, Yuchi ZG, Van Petegem F. Mol. Cell.

Catecholaminergic polymorphic ventricular tachycardia patients with multiple genetic variants in the PACES CPVT registry.

Roston TM*, Haji-Ghassemi O*, LaPage MJ, Batra AS, Bar-Cohen Y, Anderson C, Lau YR, Maginot K, Gebauer RA, Etheridge SP, Potts JE, Van Petegem F, Sanatani S.  Plos One. [*co-first]

Structural basis of cell wall anchoring by slh domains in paenibacillus alvei. Nat. Commun.

Blackler RJ, Lopez-Guzman A, Hager FF, Janesch B, Martinz G, Gagnon SML, Haji-Ghassemi O, Kosma P, Messner P, Schaffer C, Evans SV. Nat. Commun.

Conserved residues Arg188 and Asp302 are critical for active site organization and catalysis in human ABO(H) blood group A and B glycosyltransferases.

Gagnon SML, Legg MSG, Polakowski R, Letts JA, Persson M, Lin SJ, Zheng RB, Rempel B, Schuman B, Haji-Ghassemi O, Borisova SN, Palcic MM, Evans SV. Glycobiology.

Polyspecificity of anti-lipid A antibodies and its relevance to the development of autoimmunity.

Haji-Ghassemi O, Gagnon SML, Muller-Loennies S, Evans SV. Adv. Exp. Med. Biol.

The combining sites of anti-lipid A antibodies reveal a widely-utilized motif specific for negatively charged groups.

Haji-Ghassemi O, Muller-Loennies S, Rodriguez T, Brade L, Grimmecke HD, Brade H, Evans SV. J. Biol. Chem.

Molecular basis for recognition of the cancer glycobiomarker, LacdiNAc (GalNAc[ß1-4]GlcNAc), by Wisteria floribunda Agglutinin.

Haji-Ghassemi O, Gilbert M, Spence J, Schur MJ, Parker MJ, Jenkins ML, Burke JE, van Faassen H, Young NM, Evans SV. J. Biol. Chem.

High resolution structures of the human ABO(H) blood group enzymes in complex with donor analogs reveal that the enzymes utilize multiple donor conformations to bind substrates in a stepwise manner.

Gagnon SML, Meloncelli PJ, Zheng RXB, Haji-Ghassemi O, Johal AR, Borisova SN, Lowary TL, Evans SV. J. Biol. Chem. 

Antibody recognition of carbohydrate epitopes.

Haji-Ghassemi O, Blackler RJ, Martin Young N, Evans SV. Glycobiology.

Structural basis for antibody recognition of lipid A: Insights to polyspecificity toward single stranded DNA.

Haji-Ghassemi O, Müller-Loennies S, Rodriguez T, Brade L, Kosma P, Brade H, Evans SV. J. Biol. Chem.

Groove-type recognition of Chlamydiaceae-specific lipopolysaccharide antigen by a family of antibodies possessing an unusual variable heavy chain N-linked glycan.

Haji-Ghassemi O, Müller-Loennies S, Saldova R, Muniyappa M, Brade L, Rudd PM, Harvey DJ, Kosma P, Brade H, Evans SV. J. Biol. Chem.